Malaria is one of the most common concerns for travellers — particularly families with young children — when planning an African safari. The good news is that South Africa has several outstanding Big Five game reserves that are completely malaria-free. You do not have to compromise on wildlife quality to avoid antimalarial medication.
Understanding the Malaria Map
In South Africa, the malaria risk area is concentrated in the northeastern Lowveld — primarily the Kruger National Park, the Sabi Sands and surrounding private reserves. The risk is highest during the wet summer months from October to April, and very low during the dry winter months. Outside of the Lowveld, the rest of South Africa is malaria-free.
Madikwe Game Reserve
The standout choice for a malaria-free Big Five safari. Located on the Botswana border, Madikwe is the fifth largest reserve in South Africa and home to lion, leopard, elephant, rhino, buffalo, cheetah, wild dog and brown hyaena. A wide range of lodges from family-friendly to exclusive boutique. Around four hours from Johannesburg or a short charter flight.
Tswalu Kalahari
Deep in the Northern Cape’s Kalahari — well outside any malaria zone. While a very different safari experience to the Lowveld, it is completely malaria-free and one of the most exclusive reserves in Africa. Ideal for families with young children, given the private vehicle policy.
Shamwari and the Eastern Cape
The Eastern Cape reserves — Shamwari, Kwandwe, Amakhala and Kariega — are malaria-free and offer a solid Big Five experience. The landscape is quite different from the Lowveld, with valley bushveld, grasslands and riverine forest. Several are accessible from Gqeberha (Port Elizabeth), making them easy to combine with the Garden Route.
Pilanesberg Game Reserve
Just two hours from Johannesburg in an ancient volcanic crater. Big Five game viewing in a malaria-free setting. More accessible and busier than private reserves, but an excellent option for short safaris — particularly as a first introduction for families.
A Note on the Lowveld in Winter
The malaria risk in the Sabi Sands and Kruger drops dramatically during the dry winter months from May to September. Many doctors consider the risk negligible during this period. If you have your heart set on the Sabi Sands but are concerned about malaria, a winter trip is worth considering — the game viewing is also at its best.
We regularly plan malaria-free safaris for families and travellers who prefer to avoid prophylaxis. Get in touch and we will find the perfect destination for you.